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    • Home
    • About
    • Knobology
      • What is Ultrasound
      • Cardinal Movements
      • Ultrasound Modes
      • Ultrasound Artifacts
    • Cardiac
      • Basic Cardiac Views
      • LV Function
      • RV Function
      • Basic Valve Assessment
      • Aortic Regurgitation
      • Aortic Stenosis
      • Mitral Regurgitation
      • Tricuspid Regurgitation
    • Lung
      • Lung Assessment
      • Pneumothorax
      • Pleural Effusion
      • Pneumonia
    • Volume
      • JVP
      • IVC
    • Abdomen/Renal
      • FAST Exam
      • Hydronephrosis
    • Advanced
      • LVOT VTI
      • VEXUS
    • Procedures
      • Disclaimer
      • Arterial Line
      • Central Line
      • Dialysis Line
      • Lumbar Puncture
      • Paracentesis
      • Thoracentesis
      • Ultrasound Guided IV
      • Intubation
      • NG Feeding Tube
    • GIM Fellows
    • POCUS Selective
    • Contact
  • Home
  • About
  • Knobology
    • What is Ultrasound
    • Cardinal Movements
    • Ultrasound Modes
    • Ultrasound Artifacts
  • Cardiac
    • Basic Cardiac Views
    • LV Function
    • RV Function
    • Basic Valve Assessment
    • Aortic Regurgitation
    • Aortic Stenosis
    • Mitral Regurgitation
    • Tricuspid Regurgitation
  • Lung
    • Lung Assessment
    • Pneumothorax
    • Pleural Effusion
    • Pneumonia
  • Volume
    • JVP
    • IVC
  • Abdomen/Renal
    • FAST Exam
    • Hydronephrosis
  • Advanced
    • LVOT VTI
    • VEXUS
  • Procedures
    • Disclaimer
    • Arterial Line
    • Central Line
    • Dialysis Line
    • Lumbar Puncture
    • Paracentesis
    • Thoracentesis
    • Ultrasound Guided IV
    • Intubation
    • NG Feeding Tube
  • GIM Fellows
  • POCUS Selective
  • Contact

Intubation

Indications for Intubation

  • Poor oxygenation 
    • PaO2 low (i.e. < 60 mmhg) despite maximally delivered non-invasive methods. 
  • Poor ventilation
    • PaCO2 elevated above patient’s baseline despite non-invasive methods, with ongoing acidosis.
    • Suspected neuromuscular disease (i.e. GBS, myasthenia) with vital capacity < 20ml/kg, MIP < 30 cmH2O, MEP < 40 cmH2O, 20:30:40 rule.
    • Cervical spine injury with diaphragmatic paralysis. 
  • Unprotected airway.
    • Decreased LOC with loss of airway reflexes (often GCS < 8).
    • Impending airway collapse: thermal burns, anaphylaxis, epiglottitis, severe drug overdoses, expanding neck hematoma or mass.
    • Airway trauma.
    • High risk of aspiration i.e. ongoing hematemesis in UGIB.
  • Performing surgery/procedures that require general anesthetic.
  • Impending respiratory failure.
    • Cyanosis, diaphoresis, tachypnea/tachycardia, heavy accessory muscle use.
    • Concern of muscle fatigue (i.e. persistently elevated respiratory rate). 
  • Airway safety following high dose sedating medication use i.e. seizure termination in status. 
  • To facilitate short term hyperventilation to manage increased ICP. 
  • Transportation safety in patient at high risk of decompensation, i.e. high dose sedation for psychosis, trauma requiring imaging, etc.

Tools required for intubation: STOPMAID

  • Suction
    • Have two suction devices ready
    • ‘Ducanto’ or other large bore suction device should be available if anticipate heavy bleeding or vomiting interfering with airway. 


  • Tools for intubation
    • Hyperangulated blade (i.e. ‘Glidescope’)
      • Default Glidescope #3 blade for women and #4 blade for men. 
      • Note: At KGH first pass is often done with glidescope 4 video laryngoscopy, but should have direct laryngoscope, bougie, BVM, and OPA/NPA/LMA available, and surgical access kit in emergent situation of can’t ventilate/can’t oxygenate.


  • ET tube x2 sizes.
    • Generally, size 7-7.5 for women, 7.5-8 for men. 
      • Keep a size above and below in the room ready.
    • Stylet (bend to match curvature of hyper angulated blade).
    • 10ml syringe to inflate cuff (+ manometer to ensure cuff pressure 20 – 30 cmH2O).
    • ETT securement device or tape.


  • Oxygen source.
    • Two sources!: nonrebreather mask + nasal prongs for preoxygenation.
    • BVM with reservoir + end tidal CO2 monitor.
    • Mechanical ventilator set up by RT.


  • Positioning tools
    • I.e. pillows, Troop pillow, elevating head of bed to facilitate “sniffing” position. 
    • Note: sniffing = aligns airway axis. Ideally want to be able to see from the side of patient the earlobe lining up with the sternal notch. 


  • Monitors
    • Continuous cardiac monitoring and pulse oximetry.
    • Non-invasive BP cycling q1-2 minutes.
    • Invasive BP monitoring (Arterial line) ideal in hemodynamic instability.


  • Assistants
    • RT available to assist with bag-mask ventilation and intubation.
    • Nursing for drug administration. 
    • Second physician to monitor and manage hemodynamics if possible.


  • Intravenous access
    • Ideally want 2 or more peripheral IVs at a minimum. 


  • Drugs
    • Induction agent(s).
    • Neuromuscular blocking agent.
    • Vasopressors.

Induction Agents:

Ketamine

  1. Intubation dose:1-2 mg/kg (i.e. 100 mg IV is a good dose for most patients).
  2. Time to effect: 45-60 seconds.
  3. Duration of action: 10-20 minutes.
  4. Benefits:
    1. Hemodynamically stable (usually), can expect some tachycardia.
    2. Bronchodilation, generally maintains respiratory drive (although apnea may still occur at doses >0.5mg/kg).
  5. Side effects:
    1. Potential sympathetic stimulation (increased HR, BP, ICP).
  6. Ideal use:
    1. Trauma.
    2. Maintaining spontaneous respiration.
    3. Significant hypotension.
    4. Note: if patient is catecholamine deplete, can lead to hypotension
    5. Severe bronchospasm (i.e. asthma).
  7. Caution in: 
    1. Severe hypertension (may need adjunct (ex. opioid) to blunt sympathetic response).
    2. Aortic dissection patients (need to avoid sympathetic drive).
    3. Severe CAD or severe CHF (due to increased myocardial demand).
    4. Note: Classically ketamine was used with caution in significantly elevated ICP (due to sympathetic stimulation), but recent studies question this.
    5. Note: In high ICP clinical judgement is needed with its use. 

Propofol

  1. Induction dose: 0.5-2 mg/kg IV. 
  2. Time to effect: 15-45 seconds.
  3. Duration of action: 5-10 minutes.
  4. Benefits: Anesthesia, amnesia, bronchodilation, seizure aborting agent. 
    1. Note: no analgesia. 
  5. Side effects
    1. Hypotension (peripheral vasodilation), eliminates respiratory efforts. 
  6. Caution in 
    1. Hemodynamic instability, especially in increased ICP/head trauma.
  7. Ideal use
    1. Hypertensive emergencies.
    2. Hemodynamically stable patients.
    3. Status epilepticus. 

Etomidate (rarely used at KGH)

  1. Intubation dose: 0.3mg/kg. 
  2. Time to effect: 15-45 seconds.
  3. Duration of action 3-12 minutes.
  4. Benefits:
    1. Cardiac stability.
  5. Side effects: 
    1. Adrenal insufficiency, significant nausea.
  6. Ideal use: 
    1. Significant cardiac dysfunction.
    2. Significant hypotension (can reduce dose to 0.15mg/kg).
    3. Significantly increased ICP. 
  7. Caution in:
    1. Adrenal insufficiency or significant sepsis.

MIdazolam

  1. Induction dose: 1-5mg IV.  
  2. Time to effect: 30-60 seconds.
  3. Duration of action: 15-30 minutes.
  4. Benefits:
    1. Anxiolysis, amnesia, antiepileptic.
    2. Note: no analgesia 
  5. Side effects:
    1. Hypotension in high doses.
  6. Ideal for:
    1. Hemodynamic instability.
    2. Status epilepticus. 
  7. Caution in: 
    1. Significant shock.


Fentanyl

  1. Induction dose: 50-150mcg.
  2. Time to effect: 1-2 minutes.
  3. Duration of effect: 30-60 minutes.
  4. Benefits: 
    1. Analgesia, anesthesia, sympatholytic.
  5. Side effects: 
    1. Hypotension (when combined with benzos or propofol), decreased respiratory drive, risk of awareness if used as a sole agent.
  6. Ideal for: 
    1. Reducing sympathetic drive during laryngoscopy in hypertension, sympathetically driven states, high ICP, globe rupture.
  7. Caution in: 
    1. Shock states.

Clinical Scenario Suggestions for Induction Agent:

  1. Head Injury with hypertension: etomidate +/- fentanyl.
  2. Head injury with normotension/hypotension: ketamine or etomidate +/- fentanyl.
  3. Status epilepticus: propofol or midazolam.
  4. Shock/hypotensive patient: ketamine or etomidate.
  5. Patient with severe cardiac disease: etomidate.
  6. Status asthmaticus: ketamine or propofol.
  7. Aortic dissection: etomidate or midazolam

Vasopressor and inotropic support:

Phenylephrine

  1. Dose: Push dose 100-200mcg IV, infusion 0-100mcg/min IV.
    1. Typically used as push-dose.
  2. Use for:
    1. Peripheral dilation secondary to induction agents.
  3. Side effects: 
    1. Reflex bradycardia possible, hypertension.

Norepinephrine

  1. Dose: Push 4-16mcg IV, infusion 0-35mcg/min IV.
    1. Typically used as an infusion (often initiated prior to induction to avoid hypotension).
  2. Use for: 
    1. Peripheral dilation or cardiac dysfunction (beta-agonist limits reflex bradycardia and provides inotropy).
  3. Side effects: 
    1. Hypertension, tachycardia.


Epinephrine

  1. Dose: Push 1-100mcg IV, infusion 0-35mcg/min IV.
    1. Typically used as an infusion or push-dose in a peri arrest scenario.
    2. 1mg push dose in ACLS algorithm.
  2. Use for: 
    1. Significant hemodynamic instability or cardiac dysfunction with peripheral vasodilation.
  3. Side effects: 
    1. Hypertension, tachycardia, elevated lactate, increased cardiac demand.

When to consider awake intubation

  1. Indications:
    1. Anticipated severe difficult airway (anatomic or physiologic). 
    2. Patients at risk of decompensation when administer induction drugs (i.e. hemodynamic instability).


  1. Contraindications:
    1. Patient requiring immediate intubation = RSI.
    2. Combative or uncooperative.
    3. Allergy to local anesthetic.
    4. Patients with excessive airway bleeding or secretions. 

Neuromuscular blocking agents

Rocuronium (non-depolarizing, commonly used)

  1. Intubation dose: 0.6-1.2 mg/kg IV (RSI dose 1.2mg/kg).
  2. Time to paralysis: 45-60 seconds.
  3. Duration of action: 45 minutes.
  4. Benefits: 
    1. Fast, no increase to serum potassium, commonly used.
  5. Caution in:
    1. High risk/anatomically difficult airways (risk of soft tissue collapse). 
  6. Reversal agent: sugammadex. 

Succinylcholine

  1. RSI dose: 1-2mg/kg IV.
  2. Paralysis time: occurring after 30-45seconds.
  3. Duration of action: 6-10 minutes.
  4. Contraindications:
    1. Malignant hyperthermia (personal or family history).
    2. Prolonged immobilization.
    3. Neuromuscular disease (muscular dystrophy, ALS, GBS, MS, spinal cord injury).
    4. Stroke > 72h old.
    5. Rhabdomyolysis.
    6. Burn > 24h old.
    7. Hyperkalemia.
    8. Pseudocholinesterase deficiency.
  5. Side effects
    1. Hyperkalemia.
    2. Trismus/masseter muscle spasm.
    3. Fasciculations.
    4. Bradycardia.
    5. Possible increase in intraocular pressure. 

Pre-intubation quick assessment:

History

  1. Prior difficult intubation, history of restricted neck mobility (e.g. cervical spine arthritis, ankylosing spondylitis, prior cervical neck surgery/fixation), abnormal tissue anatomy/mobility (ex. oropharyngeal cancer, radiation to head/neck), active head/neck pathology or mass/distortion.


Physical Examination

Assess for ease of intubation, bag-mask ventilation, and front of neck access.


  1. LEMON (Assess for intubation difficulty)
    1. Look externally (assess for trauma, short neck, small mouth, enlarged tongue, prominent teeth)
    2. Evaluate 3-3-2
      1. 3: mouth opening should be at least 3 fingers (5-6cm).
      2. 3: tip of chin to hyoid bone at least 3 fingers (5-6cm).
      3. 2: distance from the hyoid to thyroid cartilage (Adam’s apple) at least 2cm.
    3. Mallampati score
      1. Class 1 = soft palate +full uvula.
      2. Class 2 = soft palate + partial uvula.
      3. Class 3 = soft palate only. 
      4. Class 4 = hard palate only.
    4. Obstruction
      1. Assess for soft tissue swelling, tumors, foreign bodies. 
    5. Neck mobility 
      1. See if can extend neck (sniffing position).


  1. BONES (Assess for BMV difficulty).
    1. Beard – difficult to seal mask.
    2. Obesity – risk of obstruction from redundant oropharyngeal tissue.
    3. No teeth – risk of soft tissue obstruction.
    4. Elderly – reduced tissue elasticity.
    5. Snoring/sleep apnea – risk of soft tissue obstruction.

Procedural Steps:

Patient preparation and setup

  1. Ensure all equipment ready (see above checklist).
    1. Monitors (BP cuff q1-2 minutes, pulse oximetry, ECG, EtCO2). 
    2. Two sources of oxygen delivery (i.e. nonrebreather + nasal prongs).
    3. Bag-mask-ventilation (BVM + reservoir + PEEP valve +- OPA +- NPA).
    4. Suction
    5. Intubation equipment
      1. Laryngoscope (DL or video, MAC 3 or 4 blade).
      2. Endotracheal tube (multiple sizes, stylets to match curve of blade).
      3. 10cc syringe to inflate cuff + ETT securement device or tape.
    6. BVM + PEEP valve.
    7. EtCO2 monitor (qualitative or quantitative).
    8. IV access + RSI drugs + rescue drugs. 
    9. Consider pre-emptive vasopressors (infusion + bolus dose). 
    10. Have a backup plan (2-3) and prep your backup equipment (i.e. LMA, bougie, scalpel for front of neck access).
      1. Backup personnel (i.e. RT, staff, anesthesia).
  2. Place patient in sniffing position + bed at comfortable position for intubation.
    1. Special situations:
      1. If C-collar in place = neutral position + inline stabilization by extra personnel not sniffing.
      2. If obese = head elevated 10 – 30 degrees.  
  3. Pre-oxygenate with 100% O2 - non-rebreather + nasal prongs, 3-5 minutes. 

RSI Medication Delivery + Intubation

  1. Perform timeout – verify equipment, team roles, and verbalize plan A, B, and C.
  2. Push RSI medications (i.e. ketamine, rocuronium).
    1. Keep nasal prongs on patient at high flow rate.
  3. Laryngoscopy.
    1. Insert laryngoscope into mouth along the tongue (video laryngoscopy) or sweep tongue to the left (direct laryngoscopy).
    2. Walk your blade down the airway, identifying key structures along the way (valleculoscopyepiglotoscopy laryngoscopy).
    3. Insert tip of laryngoscope into the vallecular space.
    4. Lift the blade up to visualize vocal cords (don’t rock your wrist backwards!).
      1. Verbalize your view to the others in the room.
  4. ET tube insertion
    1. Insert ETT into mouth and advance until seen on screen with the laryngoscope.
    2. Under video guidance, advance ET tube into the trachea.
    3. Remove stylet slowly while passing through the vocal cords.
  5. Ensure cuff is just past the vocal cords then inflate cuff while maintaining view.
  6. Attach BMV and confirm tube placement
    1. Visualizing chest rise, observing misting in the endotracheal tube, detecting appropriate EtCO2, and auscultating bilateral breath sounds.
    2. Note: Waveform capnography is gold standard for verification. 
  7. Secure ET tube + connect to ventilator (with assistance from RT). 
  8. Order chest x-ray to verify tube depth (ideally 2-3cm from carina).

Maintenance Sedative

Choosing a sedative

  1. Opiates (i.e. fentanyl) 
    1. Most regimens of sedation should include an opiate first (for analgesia).
  2. Propofol
    1. Caution in hypotension. 
    2. Does not provide analgesia. So only used in isolation when needing rapid on/off for frequent neurological checks.
  3. Midazolam
    1. Good in hemodynamic instability, alcohol withdrawal, significant pain
  4. Dexmedetomidine
    1. Good for long term use, minimizing sedation while tolerating ETT.
    2. Caution in hypotension, bradycardia (alpha blocker, will make bradycardia worse)

Choosing sedatives by scenario

  1. Bradycardia
    1. Avoid dexmedetomidine.
  2. Obesity
    1. Avoid benzos = accumulate in adipose tissue.
  3. Prolonged qtc
    1. Avoid antipsychotics (i.e. Haldol).
  4. Severe Hypotension
    1. Avoid propofol or dexmedetomidine.
  5. Severe hypertriglyceridemia
    1. Avoid propofol.
  6. Renal impairment
    1. Avoid high dose lorazepam (propylene glycol can accumulate = toxic).
  7. Consider lower doses of all sedatives due to accumulation.

Causes of Sudden Hypoxia on Ventilator:

DOPE

  • Dislodged tube (always consider right mainstem).
  • Obstruction
    • Obstruction of tube (e.g. mucous).
    • Airway obstruction- bronchodilators, air trapping ventilator adjustments.
  • Pneumothorax.
  • Equipment failure.



Document written by: Muraile Vignarajah MD (Internal Medicine), Michael Taylor MD (Anesthesia)

Staff Reviewed by: Dr. Nicole Rocca (Emergency Medicine, Critical Care)

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Resources: cpocus.ca, EDE Handbook, UBC POCUS Gallery, POCUS101.com

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